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Disclaimer- The information provided here is for educational purposes, I am not a medical professional nor a genetics professional. While I can describe some of the things I have learned and researched, each individual is different and what worked for me may not work for you.

Genealogy Resources

Distant Ancestors: http://www.geneajourney.com/welcome.html#top or http://www.geneajourney.com/overton.html#top this site has some well researched lineages that go back to early American and European times. Dig around, there is a wealth of information. Thanks to whomever put this site together. I found it while looking at the Overton lineage.

FamilySearch.com: https://familysearch.org/ This is the Latter Day Saints (LDS) Mormon website. They have extensive information at their library in Utah on families as they have been collecting it for over 50 years. It has a free account to set up you lineage and some nice search tools. I have found it most useful and made amazing discoveries about my ancestors. It automatically announces links to other peoples work when you have entered identical information and can produce lineages going back quite far in time when you connect to these.

Ancestry.com: http://www.ancestry.com/ This is a well known website for genealogy and does require a paid subscription. Also see their alternative site for genealogy: http://www.ancestry.com/genealogy/

GenealogyBank.com: http://www.genealogybank.com/gbnk/ This is subscription site for looking up old articles and records. You are not allowed to post to the web any copies of what you find due to copyright issues. I contacted them about this as it is the cornerstone of geneaolgy to find actual documentation and the reply said it could be paraphrased so that is what I have done.

BillionGraves.com: https://billiongraves.com/ This site is still developing but does have listing from all over the world. It is a subscription site that relies heavily on volunteers to catogorize and list cemeteries.

Find A Grave: http://www.findagrave.com/ This site is great for looking up ancestors. It has a surprising number of my ancestors listed. You can sort by state, do a unversal search to broaden it out and find some family origins or find a family member, then click on the linked cemetery and see if there are others. It is also volunteer oriented but much farther along in development. It is a free website, supported by advertising.

MyHeritage: https://www.myheritage.com This is site that is fairly fun but is does require a subscription, it allows you to import a GEDCOM file from other sources and geneaolgy programs so you don't have to enter everything again. This is a nice option as they are tied into FamilySearch and so present a lot of information that is already in FamilySearch. I know this as they kept presenting the very information that I entered in FamilySearch. It does have some nice searching tools for documentation searches and is tied into BillionGraves as part of the suscription and gravestone entries can be found on a search. You can also link your DNA test from 23andMe and find more cousins. It is also useful for linking up with other relatives established lineages with the chance you may be able to fill in some of those brick walls that are occasionally found. The only drawback I have found is that I now have about 1000 entries from other people awaiting my confirmation that these relatives from 2 source lines are indeed the same. MyHeritage purchased Promethease and SNPedia in December 2019.

AmericanAncestors at New England Historic Genealogical Society: http://www.americanancestors.org This is the premier organization for genealogical research in New England for upper northeast part of the United States. Otherwise referred to as NEHGS. It is a subscripton site but has numerous records and books for the hardcore genealogist. They have recently added a section called the Jewish Heritage Center. I have found marriage records for ancestors from the early 1700's. They stick to New England and early British records for most part.

JSTOR: http://www.jstor.org Information on some family genealogies has been put together in older magazines that can be found on JSTOR, like The Virginia Magazine of History and Biography. I have found that some of the family histories in these old magazines are not always accurate but usually very close and still need verification. JSTOR is a subscription site for journals although some of the older publications can be found for free. You may be able to access JSTOR from a public library or university library.

Fold3: https://www.fold3.com/ This is the site to use for researching millitary history of ancestors. It is related to Ancestry.com.

GEDmatch: https://www.gedmatch.com This site is popular and used by people looking for relatives and genealogy information. They use files from 23andMe, FTDNA (FamilyTree) and AncestryDNA.com. It allows you to search for current relatives from ancestors farther back in time by bypassing the common limit of 7 Centimorgans (cM) and going to 4 if you want. You can also pull up your Ethnic mix with a variety of options. The website is free. As of December 2019, GEDmatch has been bought by Verogen, Inc, a forensic genomics company. Please be sure to read the privacy statement and options as this company is using the available genomic data from GEDmatch for criminal investigations. You can opt in or out participation with law enforcement but be aware that this was already violated when owned by GEDmatch, when presented with a warrant in one case that allowed law enforcement access to all data regardless of opting in or out. I opted to delete my information, it is not for sale.

History at Home: A Guide to Genealogy by Home Advisor: http://www.homeadvisor.com/r/guide-to-genealogy/#.WJXyNBCgU3g
Here is a website article on beginning your genealogy research for those that are new to this, with numerous links to articles, tips, government archives, documenting ancestors and more. Thanks go out to the kids and their mentor for this link.

Claire’s Corner: https://job-prices.co.uk/get-started-with-genealogy/
A page with some UK genealogy resources by Claire Mitchell, which includes a basic guide on getting started in genealogy. Scroll down a bit for access to UK specific links for genealogy research.

 

Genetics Resources

Genetics Course from Coriell Institute for Medical Research https://cpmc.coriell.org/genetic-education/overview

National Human Genome Research Institute, Online Genetics Education Resources: https://www.genome.gov/10000464/online-genetics-education-resources/ This site has multiple listings and links to genomic education.

Genetics Home Reference, U.S. National Library of Medicine: https://ghr.nlm.nih.gov/gene This is a great site for looking up genes. They have brought together many types of information and links.

Honest Product Reviews- Best DNA Test for Ancestry. https://honestproductreviews.com/best-dna-test-for-ancestry/ This is a good overview of the pros and cons regarding different DNA testing services and which one you might want to use. They have a complete review of the major testing companies as well as reasons you might want to test. It is really a primer on what to expect from DNA testing and addresses many questions and concerns you might have.

23andMe: https://www.23andme.com This company has a Ancestry only genetics test for $99.00. You can also get Ancestry and Health for $199.00. Either test will povide the raw data. They are currently providing a limited amount of health reports but you can get your raw data, save it to your computer and there are a few other places where you can generate reports using that data. If you are looking for pathogenic (bad) SNP's be aware that they only test about one tenth of these. Still a lot of information can be found. For more information...

dbSnp: http://www.ncbi.nlm.nih.gov/SNP/ This is a free government website where you can research each SNP (Single Nucleotide Polymorphism Database). It is a bit overwhelming so check out this introduction at http://www.ncbi.nlm.nih.gov/projects/SNP/docs/rs_attributes.html The pathogenic SNP's have colored alerts on them. You will need the RS number to enter into the search box. For more information...

OMIM: http://omim.org/ Online Mendelian Inheritance in Man, is a database of researched genetic mutations with short summary of the SNP's that have disease causing effects or produce some detrimental change. Put the Gene name in the search box, like MTHFR. They have made the interface more friendly recently. For more information...

SNPedia: http://www.snpedia.com/index.php/SNPedia An online wiki on numerous genes, here you can put either the Gene name or the RS number in the search box to research a SNP. They also provide a most useful report called Promethease which is a good alternative report since 23 and Me provides limited health information. I found it most useful. For more information...

Promethease : http://www.snpedia.com/index.php/Promethease This report is part of the SNPedia web site. For $12.00 U.S., you can have a report that will show which are the more detrimental SNP's, they will be in a red box outline. The gray boxes are undecided or there may not be enough information to make a judgement call. Often this is because there is only one report on that SNP. The green box outline are SNP's that are reported to be fine. There is a static report listing genes involved with Medicines or Medical Conditions. There is also UI version 2 (or similar) included which is an interactive way of searching specific genes, which genes are involved in certain diseases or you can sort to find just the bad genes. Promethease was purchased by MyHeritage in December 2019 so if you do not want MyHeritage to have your information, you can delete it after you get the report and download it to your computer for future use. For more information...

Livewello.com https://livewello.com/23andme This site can generate a report on about 300 SNP's for $19.95 U.S., a one time fee. They also have tools for working with multiple health care providers. This is a quick way to find out if you are homozygous for the minor allele (red), heterozygous (yellow), or homozygous for the major allele (green) for a number of common SNP's. Not all of these are pathogenic, most are normal variants but they can impact your health. This report will not tell you which is the risk allele. Most of the time it is the red ones. Livewello works with 23 and Me raw data, Ancestry.com and others.

MTHFRSupport.com http://mthfrsupport.com/ Sterling Hill and her team have a report for $30.00 U.S. They support 23andMe and Ancestry DNA. It will generate about a 50 page report which can be saved in PDF format or researched through your online account. It is similar to Livewello but with more SNP's. I am not sure how many SNP's there are because it looks like some are repeated under different catagories as many of these SNP's influence multiple pathways.

Enlis Genomics: https://www.enlis.com/ Are you are ready for a more in depth analysis, want something more sophisticated? Enlis Genonics offers free software to research your raw data from 23andMe as well as other genomic files such as Whole Exome testing. It costs to process your raw data in a form that can be used by their software. They charge $39.95 US to process a file from 23andMe, Ancestry or FTDNA. For Whole Exome tests the cost is $79.95 US.
Whole Exome testing encompasses a more complete view of your genome as relates to mutations that are related to health disorders and costs about $1000.00 US. Whole exome files will end in .vcf and are much larger.
Enlis Genomics has a personal version of their software which will require processing the data for each individual. Their other version allows for processing multiple files without using their website and is geared towards professionals, it also addresses compound mutations which is not necessarily obvious with the personal version. See their FAQ as it addresses a lot of common questions.
Enlis Genomics went thru the free online 23andMe files posted by people and reverse engineered the internal numbers, the ones that start with an “i“instead of “rs”, based on chromosomal locations and pulled out a lot more information from the 23 and me file. They also removed what they consider “over calls” of certain snps which are found in 23andMe raw data. This is where the number of reported mutations for a certain disorder are way out of the norm in relation to the population data and are probably errors.

For the Serious Genomics Explorer.

MARRVEL: http://marrvel.org/ This is a new site which is compiling the multiple data bases involved in genomic research. Worth checking out especially for those snps that are hard to find information on. It looks promising.

ExAC Browser: http://exac.broadinstitute.org/ Here you can look up snps by rs name and other forms. The Exome Aggregation Consortium (ExAC) is a coalition of investigators seeking to aggregate and harmonize exome sequencing data from a wide variety of large-scale sequencing projects, and to make summary data available for the wider scientific community. The data set provided on this website spans 60,706 unrelated individuals sequenced as part of various disease-specific and population genetic studies.

NHLBI Exome Sequencing Project (ESP) Exome Variant Server: http://exac.broadinstitute.org/

ClinGen Pathogenicity Calculator: http://calculator.clinicalgenome.org/site/cg-calculator
I found this to be very helpful, if you come across variants described as “Novel” within Enlis Software. Some of these “Novel” designations are just an error in connecting with dbSnp populations but I found many that are rare variants with no information but if you login and you can put the rs number or some of the designated descriptors used, like NC_000002.11:g.242077496C>T. You can look at the population information that is available and whether it is considered “Probably Damaging” or “Benign” or “Tolerated” or a “Loss of Function (LOF)” mutation etc...