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Disclaimer- The information provided here is for educational purposes, I am not a medical professional nor a genetics professional. While I can describe some of the things I have learned and researched, each individual is different and what worked for me may not work for you.


Promethease : http://www.snpedia.com/index.php/Promethease

Promethease was purchased by MyHeritage in December 2019 so if you do not want MyHeritage to have your information, you can delete it after you get the report and download it to your computer for future use.

This report is part of the SNPedia web site. For $12.00 U.S., you can have a report that will show which are the more detrimental SNP's, they will be in a red box outline. The gray boxes are undecided or there may not be enough information to make a judgement call. Often this is because there is only one report on that SNP. The green box outline are SNP's that are reported to be fine. There is a static report listing genes involved with Medicines or Medical Conditions. There is also UI version 2 (or similar) included which is an interactive way of searching specific genes, which genes are involved in certain diseases or you can sort to find just the bad genes.

For an example of the Interactive report: http://files.snpedia.com/reports/promethease_data/genome_Mike_Spear_pooled_ui2.html

On the interactive report, under Repute on the right side menu, click off the Good and Not Set options to isolate the bad SNP's. On average it seems that there are between 200 and 300 of these bad SNP's listed for most of the reports I have looked at so don't panic. We all have some less than stellar genetics.

Set Allow to about 200 or 320 to see them all. If you want to see all the really bad ones called Pathogenic, click on the ClinVar big button on the right side and set the options to Pathogenic and Probable Pathogenic, click off all else. There will be more pathogenic ones listed under Not Set so have both Not Set and Bad clicked on to see these. The Not Set ones will be in a gray outlined box. I have found that it does not necessarily mean those are not bad, the gray box just means there might only be one report or study that says it is bad and it has not been verified by other research reports so approach it with caution. It may in fact be something that has an effect but they can't call it bad because of the lack of available information. I would encourge you to look at those as well but you will have to determine if your SNP configuration is on the bad or good side as it won't reveal that. Just because it is listed as Pathogenic in the gray outlined box does not mean you have that configuration that will cause a problem. The red outline boxes however do usually mean you have the more detrimental configuration.

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